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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4820 | Maleimide | 2,5-Pyrroledione | Others |
Maleimide (2,5-Pyrroledione) (2,5-Pyrroledone) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its b... | |||
T18479 | NH-bis(C1-Boc) | Others | |
NH-bis(C1-Boc)is a uncleavable linker. NH-bis can be used for antibody-drug conjugates (ADC). | |||
T21408 | DM1-SMe | DM1-SSMe | Microtubule Associated |
DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell ... | |||
T4289 | Mc-Val-Ala-PAB | Mc-Val-Ala-PAB | Others , AChR |
Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC). | |||
T14061 | EMCS | 6-Maleimidohexanoic acid N-hydroxysuccinimide ester | Others |
EMCS (6-Maleimidohexanoic acid N-hydroxysuccinimide ester) is a heterobifunctional crosslinking agent, which is a compound for the preparation of hapten conjugate and enzyme immune conjugate, and an effective protective ... | |||
T76769 | Indusatumab | Guanylate cyclase | |
Indusatumab (5F9 Monoclonal antibody) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody that can be used to synthesize antibody-drug conjugate. | |||
T16899 | SMCC-DM1 | DM1-SMCC | Others |
SMCC-DM1 (DM1-SMCC) (DM1-SMCC) is a drug-linker conjugate which composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody-drug conjugate (ADC). | |||
T1910 | Ansamitocin P 3' | Maytansinol butyrate,Ansamitocin P-3,Antibiotic C 15003P3' | Microtubule Associated |
Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity. | |||
T77406 | Lorvotuzumab | Others | |
Lorvotuzumab (Anti-NCAM1/CD56 Reference Antibody (lorvotuzumab)) is a humanized monoclonal antibody that binds to CD56 (NCAM1). Lorvotuzumab can be used to synthesize antibody-drug conjugate (Lorvotuzumab mertansine). | |||
T15141 | DM4 | Ravtansine | Others , Microtubule Associated |
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division. | |||
T16031 | McMMAF | Maleimidocaproyl monomethylauristatin F | Microtubule Associated |
McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC linker), which is ready to conjugate to antibody or other prote... | |||
T18529 | PDEC-NB | 4-Nitrophenyl 2-(Pyridin-2-Yldisulfanyl)Ethyl Carbonate | Others |
PDEC-NB (4-Nitrophenyl 2-(Pyridin-2-Yldisulfanyl)Ethyl Carbonate) is a disulfide cleavable linker. PDEC-NB can be used for the antibody-drug conjugate (ADC). | |||
T5149 | MC-Val-Cit-PAB | Others , AChR | |
MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker. | |||
T18870 | Vc-MMAD | Others | |
Vc-MMAD, a drug-linker conjugate for Antibody-Drug Conjugates (ADCs), combines the ADC linker Val-Cit (Valine-Citrulline) with the potent tubulin inhibitor MMAD. This compound leverages the targeting capability of ADCs t... | |||
T17731L | CL2A-SN-38 DCA 1279680-68-0(free base) | Others | |
CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibito... | |||
T15176 | DSS Crosslinker | Others | |
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).It is a homobifunctional crosslinker that is cell membrane permeable. DSS crosslinker has amine-reactive NHS esters a... | |||
T77909 | Mirzotamab | ||
Mirzotamab, an IgG1κ antibody, targets CD276/B7-H3 and conjugates with Clezutoclax, a BCL-2 inhibitor, to create Mirzotamab clezutoclax. This antibody-drug conjugate (ADC), identified as ABBV-155, is currently under inve... | |||
T4286 | Fmoc-Val-Ala-PAB-OH | Fmoc-Val-Ala-PAB | Others , AChR |
Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-paclitaxel conjugates... | |||
FL0195 | N-Boc-4-hydroxy-L-proline methyl ester | ||
N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction[2]. | |||
T9227 | Val-Ala-PAB | Others | |
Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their a... |